Annona muricata has been attributed with numerous health benefits – including anticancer properties. The aim of this study was to carry out anticancer. Annona muricata L. (A. muricata) is a species of the Annonaceae family that has been . The increasingly popular use of A. muricata as an anticancer treatment. Extensive anticancer investigations have been conducted on A. muricata due to its reported ethnomedicinal uses against.

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Immunoediting which describes the relation between immune response and tumor development occurs in three phases. Nevertheless, this last result prompted the authors to perform fractionation to identify compounds with effectiveness against M. However, other positive effects of this treatment included improvements in blood lipid levels, specifically a decline in diabetes-induced levels of LDL, total cholesterol, and triglycerides and an increase in HDL [ 39 ].

Selected metabolites profiling of Orthosiphon stamineus Benth leaves extracts combined with chemometrics analysis and correlation with biological activities.

In addition to cancer chemopreventive and chemotherapeutic effects, graviola extracts and their constituents, individually or in combination, have shown therapeutic properties for other ailments that afflict humankind including chronic inflammatory and oxidative diseases, wounds, and noninfectious and infectious microbial and parasitic diseases.

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Annona muricata is widely known as soursop due to the sour and sweet taste of its fruit. Towards a pan-European definition of complementary and alternative medicine—a realistic ambition? In the previous phytochemical investigations, more than acetogenins have been reported from the leaves, stems, bark, seeds, pulp, and fruit peel of A. An investigation of the health beliefs and motivations of complementary medicine clients.


Based on previous investigations, reticuline and cureximine are the most abundant alkaloids in A. Several studies have investigated the ability of extracts from plants, including graviola, to treat malaria caused by Plasmodium falciparumwith particular interest in chloroquine-resistant strains of this organism.


Purified AGEs, such as annocatacin A or B [ 80 ] or annocatalin [ 81 ], have been found to induce significant cytotoxicity in Hep G2 and Hep 2,2,15 hepatic cancer cells in vitro [ 8283 ].

Selective growth inhibition of human breast cancer cells by graviola fruit extract in vitro and in vivo involving downregulation of EGFR expression. The risk factors may act singly or in concert to cause mutation of normal cells [ 4 ].

Cancer, rheumatoid arthritis, Type 1 diabetes, systemic lupus erythematosus, tuberculosis and atherogenesis, are among the most common diseases due to suppression of the immune functions.

No use, distribution or reproduction is permitted which does not comply with these terms. For acetic acid-induced 0. However, more rigorous evaluation of various plant parts, their extracts, and ultimately isolated bioactive compounds is clearly warranted. Notably, isoquinoline, aporphine, and protoberberine typed-alkaloids were the most frequently isolated from the A.

Antiproliferative and cytotoxic activities were seen in NCI-H cancer lung cells after treatment with methanol pericarp extract [ ].

The leaves are used in the bath to cure skin diseases in the Caribbean islands, Indonesia as well as in the South Pacific countries Longuefosse and Nossin, ; Boulogne et al.

However, it is advisable to avoid excessive and long term consumption mruicata products containing A. The aerial parts of graviola have been extensively studied with several reported in vitro and in vivo pharmacological activities, and have been shown to be effective in the management of several cancer types. Multiple forms of AGEs have been studied for their anticwncer that can be used against particular targets, such as insects and tumour cells.

Anticancer Properties of Graviola (Annona muricata): A Comprehensive Mechanistic Review

Indexed in Science Citation Index Expanded. This investigation evidenced the potential of the A. The accepted full name of this species is A. Cytotoxicity was not noted at the concentrations tested in this study [ 67 ]. However, a consensus was reached in that consumption of species of Annonaceae was not directly related to occurrence of atypical parkinsonism reviewed in [ 4].


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Apart from the obvious toxicity induced by chemotherapy, another side effect that might appear following radiotherapy is hypothyroidism. Quantificationof acetogenins in Annona muricata linked to atypical parkinsonism in guadeloupe.

In addition, most of the biological and pharmacological studies conducted using the crude extracts of the species are at its preliminary stages. Antinociceptive and anti-inflammatory activities of the ethanol extract of Annona muricata L. Malay herbal medicine in Gemencheh, Negri Sembilan, Malaysia.

Potential Benefits of Annona muricata in Combating Cancer: A Review

Leaf extracts have also demonstrated reduced cell viability in pancreatic Capan-1 cancer cells [ 92 ]. Evid-Based Compl Alt Med: Mechanisms of analgesic and anti-inflammatory properties of Annona muricata Linn. Protective effect of ethanolic leaf extract of Annona muricata Linn. In this comprehensive review, all significant findings from previous investigations till date on the leaves of A. Subsequently, a number of cytotoxicity studies on the A.

Conventional 3D radiation therapy has been shown to be effective in the treatment of head and neck cancers, but the side effects that follow often cause discomfort and reductions in the quality of life among patients.

A study by George also showed great potential for the use of A. Currently, there are no target-based approaches for evaluating components derived from A.