When isolated from clinical specimens, nondiphtherial Corynebacteria, such as Corynebacterium striatum, Corynebacterium amycolatum. ABSTRACT. We describe an unusual cluster of Corynebacterium striatum infections in 21 patients with chronic obstructive pulmonary disease (COPD) admitted. Objective: To evaluate the clinical significance of and describe factors associated with Corynebacterium striatum infection. Methods: A.

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Clinical significance of Corynebacterium striatum isolated from human samples. In an earlier report using the disk diffusion method, Martinez et al. There are several reports of C. Technical University of Denmark. The anatomical sites of specimens from whom the 63 C. Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K, a lipid-requiring bacterium of the human skin flora.

Our results indicate that amikacin is the preferable aminoglycoside for treatment of C. Otsuka Y, et al. The higher level of moxifloxacin resistance in our strains suggest the existence of a resistance mechanism additional to mutations in gyrA.

Corynebacterium striatum: a diphtheroid with pathogenic potential.

Although initial studies indicated that C. Twenty-nine resistance profiles were distinguished among the 59 resistant C. No bacteria species could be identified at this time. Luna VA, et al. This study was performed in accordance with the ethical guidelines of the Declaration of Helsinki Expressed proteins can be targeted for secretion through either the general secretory pathway or the twin-arginine translocation pathway.

Antimicrobial susceptibility assays Antimicrobial susceptibilities were determined by micro-dilution in cation adjusted Muller-Hinton broth and interpreted following Clinical and Laboratory Standards Institute CLSI guidelines Multidrug resistance MDRdefined as non-susceptibility to at least one agent in three or more antimicrobial categories as defined for other microorganisms 18was observed in 31 Activity of linezolid against 3, strains of uncommonly isolated gram-positive organisms: Indian Journal of Medical Microbiology.


Two pairs of isolates assigned to pulsotype E showed the same resistance profile.

Her vital signs were unstable; hence, she was immediately admitted to the intensive care unit ICU. Corynebacterium striatum -A classic pathogen eluding diagnosis.

Corynebacterium striatum: a diphtheroid with pathogenic potential.

L-Lysine production is specific to C. Campanile F, et al.

Olender A, Letowska I. Unwanted side reactions such as threonine and asparagine production can occur if a buildup of intermediates occurs, sstriatum scientists have developed mutant strains of C. Skin colonization by Corynebacterium groups D2 and JK in hospitalized patients.

In TSA, they can form grey colonies with black centers and dentated borders that look similar to flowers C. International Journal of Cosmetic Science.

Case Reports in Infectious Diseases

A year-old woman visited our emergency department because of exertional dyspnea due to severe left ventricular functional failure. Twenty out of the 24 C. Therefore, daptomycin can also be considered as an alternative to vancomycin for treatment of C. Transpl Infect Dis ;5: Clin Microbiol Rev ; In conclusion, although Corynebacterium could be isolated from a blood culture as a common contaminant, in certain case this observation could conceal a dangerous infection. J Clin Microbiol ; Boltin D, et al.

The majority of cases of C. Susceptibility of 63 Corynebacterium striatum clinical isolates to 16 antimicrobial agents.

An underappreciated community and nosocomial pathogen. PFGE is considered the gold standard in epidemiological studies of pathogenic microorganisms, providing important insights into their population structure Corynebacterium diphtheriae Diphtheria Corynebacterium minutissimum Erythrasma Corynebacterium jeikeium Group JK corynebacterium sepsis.


Rapid emergence of daptomycin resistance in clinical isolates of Corynebacterium striatuma cautionary tale. Multiple drug resistance is caused by the interplay of multiple resistance mechanisms those emerge via the acquisition of extraneous resistance determinants or spontaneous mutations. Identification, Clinical Relevance, and Antibiotic Susceptibility”.

The presence of aminoglycoside modifying enzyme AME genes common in Corynebacterium spp.

Corynebacterium striatum Bacteremia Associated with a Catheter-Related Blood Stream Infection

Please review our privacy policy. However, most of these cases are represented by patients with implanted indwelling devices or who present an immunosuppression [ 26 ].

Corynebactwrium One of the most serious problems related to treatment of the infections caused by C. Electronic supplementary material Supplementary Information K, docx. One of the most serious problems related to treatment of the infections caused by C.

This article has been cited by other articles in PMC. As with various species of a microbiota including their cousins in the genera Arcanobacterium and Trueperella striatuj, they usually are not pathogenic but can occasionally opportunistically capitalize on atypical access to tissues via wounds or weakened host corynebacteriumm. Although patients with implanted CRT-D may develop infectious endocarditis, obvious vegetation was never observed on echocardiography in these cases [ 11 ].

Author information Article notes Copyright and License information Disclaimer. The sequences of the QRDR region of the gyrA gene of 21 isolates categorized as resistant or intermediate to fluoroquinolones were compared to that of the quinolone-susceptible C.