This resource may include information that has not been approved by the US Food and Drug Administration. For full prescribing information, including. Fosphenytoin official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more. Medscape – Epilepsy dosing for Cerebyx (fosphenytoin), frequency-based adverse contraindications, pregnancy & lactation schedules, and cost information. be expressed as phenytoin sodium equivalents (PE) when prescribing; There is.

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There are many drugs which may increase or decrease plasma phenytoin concentrations. Metharbital The risk or severity of adverse effects can be increased when Metharbital is combined with Fosphenytoin. Candesartan cilexetil The metabolism of Fosphenytoin can be decreased when combined with Candesartan cilexetil.

Fosphenytoin – FDA prescribing information, side effects and uses

Desipramine The metabolism of Fosphenytoin can be decreased when combined with Desipramine. Acetyl sulfisoxazole The metabolism of Fosphenytoin can be decreased when combined prescfibing Acetyl sulfisoxazole.

Dantrolene The metabolism of Fosphenytoin can be decreased when combined with Dantrolene. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.

Inhibition of metabolism may produce significant increases in circulating phenytoin concentrations and enhance the risk of drug toxicity. The clinical course of acute phenytoin hepatotoxicity ranges from prompt recovery to fatal outcomes.

Last updated on eMC: In order to obtain rapid seizure control in patients with continuous seizure activity, IV diazepam or lorazepam should be administered prior to administration of Pro-Epanutin. Captodiame The risk or severity of adverse effects can be increased when Fosphenytoin is combined with Captodiame.

Ketazolam The metabolism of Fosphenytoin can informatoin decreased when combined fosphemytoin Ketazolam. Formaldehyde is subsequently converted informxtion formate, which is in turn metabolized via a folate dependent mechanism. Eletriptan The metabolism of Eletriptan can be increased when combined with Fosphenytoin. Letermovir The metabolism of Fosphenytoin can be decreased when combined with Letermovir.

Imidafenacin The metabolism of Fosphenytoin can be decreased when combined with Imidafenacin.

Dosing errors associated with Pro-Epanutin have resulted in patients receiving the wrong dose of Pro-Epanutin. Periodic measurement of serum phenytoin concentrations should be performed during pregnancy, and the CEREBYX dosage should be adjusted as necessary.

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Blonanserin The metabolism of Fosphenytoin can be decreased when combined with Blonanserin. Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

Eszopiclone The metabolism of Fosphenytoin can be decreased when combined with Eszopiclone. Metergoline The risk or severity of adverse effects can be increased when Fosphenytoin is combined with Metergoline. Clidinium The risk or severity of adverse effects can be increased when Clidinium is combined with Fosphenytoin. There have been several reported cases of malignancies, including neuroblastoma.

Bupropion The metabolism of Fosphenytoin can be decreased when combined with Bupropion. Levobetaxolol The metabolism of Levobetaxolol can be fosphenytoln when combined with Fosphenytoin. Flecainide The metabolism of Flecainide can be increased when combined with Fosphenytoin. Fosphenytoin is completely bioavailable following IM administration of Pro-Epanutin. In neonates Haemorrhagic syndrome has been reported in neonates born from epileptic mothers receiving phenytoin.

Reduction in rate of administration or discontinuation of dosing may be needed [see Dosage and Administration 2.

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Corticosteroids, doxycycline, estrogens, furosemide, oral contraceptives, paroxetine, quinidine, rifampin, sertraline, theophylline, and vitamin D. Ivabradine The metabolism of Fosphenytoin can be decreased when combined with Ivabradine.

However, postpartum restoration of the original dosage will probably be indicated. Hesperetin The metabolism of Hesperetin can informatino increased when combined fosphdnytoin Fosphenytoin. Deramciclane The risk or severity of adverse effects can be increased when Fosphenytoin is combined with Deramciclane. Fosphenytoin had no effect on fertility in male rats.

Etonogestrel The metabolism of Fosphenytoin can be decreased when combined with Etonogestrel. Appropriate dose, dosing volume, number of vials of Pro-Epanutin, volume of diluent, and minimum infusion time should always be calculated for the patient’s exact body weight when not included in the examples. Clinical Considerations Disease-associated maternal risk An increase in seizure frequency intormation occur during pregnancy because of altered phenytoin pharmacokinetics. Estradiol acetate The metabolism of Fosphenytoin can be increased when combined with Estradiol acetate.

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Fosphenytoin is completely converted to phenytoin following IV administration, with a half-life of approximately 15 minutes.

Loxapine The risk or severity of adverse effects can be increased when Loxapine is combined with Fosphenytoin. Additionally, when ordering and storing Fosphenytoin Sodium Injection, consider displaying the total drug content i. Lornoxicam The metabolism of Fosphenytoin can be decreased when combined with Lornoxicam. Disulfiram The fosohenytoin concentration of Fosphenytoin can be increased when prescdibing is combined with Disulfiram.

Phenytoin is metabolized by hepatic cytochrome P enzymes CYP2C9 and CYP2C19 and is particularly susceptible to inhibitory drug interactions because it is subject to saturable metabolism.

Lithium succinate The risk or severity of adverse effects can be increased when Fosphenytoin is combined with Lithium succinate. The following adverse reactions have been identified during post-approval use of fosphenytoin. Aprobarbital The risk or severity of adverse effects can be increased when Fosphenytoin is combined with Aprobarbital.

Not all pack sizes may be marketed. In pregnant women being treated for epilepsy, sudden discontinuation of antiepileptic drug AED therapy should be avoided as this may lead to breakthrough seizures that could have serious consequences for intormation woman and the unborn child.

Lumefantrine The metabolism of Infoormation can be increased when combined with Lumefantrine.

Because of the risks of cardiac and local toxicity associated with IV Fosphenytoin Sodium Injection, oral phenytoin should be used whenever possible. There have been reports of decreased bone mineral density, perscribing, osteoporosis and fractures in patients on long-term therapy with phenytoin. Prenatal phenytoin exposure is associated with an increased incidence of major malformations, including orofacial clefts and cardiac defects. The addition or withdrawal of phenytoin during concomitant therapy with these agents may require adjustment of the dose of these agents to achieve optimal clinical outcome.